Failure to Verify Morphine Concentration Leads to Repeated Overdose
Summary
The deficiency involves the facility’s failure to ensure a resident was free from significant medication errors related to Morphine administration. The resident was cognitively intact with a BIMS score of 12 and had diagnoses including Diabetes Mellitus, Anxiety Disorder, and COPD. The MDS and care plan identified the resident as dependent on staff for many ADLs and at risk for discomfort related to the end-of-life process, with directions to administer pain medications as ordered if non-medication interventions were ineffective and to evaluate the effectiveness of pain-relieving medications. A physician order specified Morphine Sulfate oral solution 10 mg/5 ml, with instructions to give 1 ml by mouth every 4 hours as needed for air hunger, which equated to a 2 mg dose per administration. Despite this order, the Morphine dispensed and received from the pharmacy was of a different concentration and labeling than ordered. The label on the plastic bag indicated a 100 ml bottle of Morphine Sulfate with directions to give 1 ml (2 mg) every 4 hours as needed, while the box label documented 30 ml Morphine Sulfate solution 100 mg per 5 ml (20 mg/ml) with directions to take 1 ml (20 mg total) every 4 hours as needed for severe pain or air hunger. The Controlled Medication Utilization Record also reflected Morphine 20 mg/ml with instructions to take 1 ml (20 mg) every 4 hours as needed. The EMAR, however, showed an order for Morphine Sulfate 10 mg/5 ml, give 1 ml every 4 hours as needed for pain or air hunger, and doses were signed out as given on three occasions. This discrepancy between the ordered concentration (10 mg/5 ml) and the dispensed concentration (20 mg/ml) was not identified or reconciled by nursing staff prior to administration. Nursing staff actions and inactions contributed directly to the medication error. One LPN reported that when she administered Morphine, she looked at the EMAR but did not look at the dosage on the EMAR or check the concentration; she focused only on the instruction to give 1 ml and relied on the bottle label and narcotic sheet, both of which indicated 1 ml equaled 20 mg. She acknowledged that she did not verify the dose against the original order and that the EMAR did not specify the milligram amount, only the volume. An RN who later administered two additional doses stated she checked the narcotic sheet and PCC, saw Morphine 20 mg/ml with instructions to give 1 ml every 4 hours as needed, and administered 20 mg doses without reviewing the original order or questioning the size of the dose. Another RN acknowledged that the process used when the Morphine was delivered did not follow the usual practice of two nurses comparing the bottle and paperwork against the order. The DON confirmed that the original order was for Morphine 10 mg per 5 ml, give 1 ml (2 mg), and stated that the nurses failed to double check the dose against the order even though it was correctly transcribed on the MAR. The pharmacist later confirmed that the pharmacy had received an order for Morphine 10 mg per 5 ml but dispensed Morphine 100 mg per 5 ml (20 mg/ml) due to an initial data entry error, and the ARNP verified that the order she wrote was for 10 mg per 5 ml, 1 ml (2 mg) every 4 hours PRN, with a maximum of 12 mg per day. The sequence of events shows that the resident received three doses of Morphine at 20 mg per dose instead of the ordered 2 mg per dose. Progress notes documented that the resident had labored breathing and air hunger, with Morphine given to assist with breathing and pain, and that the resident remained lethargic with decreased urine output and minimal intake. A subsequent note indicated that the Morphine was discontinued while awaiting a new order, and later that day the resident was found without pulse or respirations. Interviews with staff and the ARNP and primary care physician confirmed that the wrong concentration and dose of Morphine had been dispensed and administered, and that the resident had been in a declining state with end-stage COPD and hospice care. The facility’s policies required nurses to compare received medications with the MAR and clarify discrepancies before administration, and to review the five rights during medication administration, but these steps were not effectively carried out in this case, resulting in the significant medication error. Additional documentation from the facility’s incident report and staff interviews further detailed the breakdown in verification processes. Staff described that the pharmacy label and narcotic record both reflected the higher concentration and dose, and that one nurse sought informal reassurance from hospital nurses using discharge paperwork rather than verifying against the original written order or contacting the prescriber or pharmacy for clarification. Another nurse acknowledged that she did not question whether 20 mg was an appropriate dose for the resident and did not know what a normal dose would be for a hospice resident. The night shift supervisor stated he advised use of Morphine for air hunger based on the resident’s labored respirations but was unaware at the time that the wrong dose was being administered. The ARNP later discovered the discrepancy when another LPN questioned the medication, and the pharmacist confirmed that the pharmacy had dispensed the wrong concentration based on an incorrect drug selection during order entry. These combined actions and omissions by the pharmacy and nursing staff led to the administration of Morphine at ten times the ordered dose on three occasions, constituting the significant medication error identified by surveyors.
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